PeproTech重組小鼠Persephin，貨號：450-35
PeproTech重組小鼠Persephin，貨號：450-35
PeproTech重組小鼠Persephin，貨號：450-35
品牌 :PeproTech
產(chǎn)地 :美國
貨號： 450-35
規(guī)格：5ug/20ug/1mg
保質(zhì)期： 1年以上
英文名： Recombinant Murine Persephin
CAS號： 無
供應(yīng)商： 深圳子科生物科技有限公司
數(shù)量： 大量
保存條件： -20℃
|
Synonyms :
|
PSP, PSPN
|
|
Description :
|
Persephin is a disulfide-linked homodimer neurotrophic factor structurally related to GDNF, Artemin, and Neurturin. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Persephin signals through a multicomponent receptor system, composed of RET and one of four GFRα (α1-α4) receptors. The GFRα4 was first identified in chicken and was later shown to be the preferential binding subunit for Persephin. Persephin promotes the survival of ventral midbrain dompaminergic neurons and motor neurons after sciatic nerve oxotomy, and like GNDF, promotes ureteric bud branching. However, in contrast to GDNF and Neurturin, Persephin does not support survival of peripheral neurons. Recombinant murine Persephin is a disulfide-linked homodimer, composed of two 10.3 kDa polypeptide chains (96 total amino acid residues). Each chain contains seven conserved cysteine residues, one of which (Cys 63) is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration
|
|
Catalog #:
|
450-35
|
|
Source :
|
E.coli
|
|
Purity :
|
Greater than 98% by SDS-PAGE gel and HPLC analyses.
|
|
Endotoxin Level :
|
Endotoxin level is less than 0.1 ng per μg (1EU/μg).
|
|
Biological Activity :
|
The ED 50 was determined by its ability to stimulate proliferation of human thyroid carcinoma cells (TT cells) is < 0.1 ng/ml, corresponding to a specific activity of > 1 x 107 units/mg.
|
|
AA Sequence :
|
ALAGSCRLWS LTLPVAELGL GYASEEKVIF RYCAGSCPQE ARTQHSLVLA RLRGRGRAHG RPCCQPTSYA DVTFLDDQHH WQQLPQLSAA ACGCGG
|
|
PubMed Link :
|
Persephin+AND+Mouse
|
|
Country of Origin :
|
USA
|
