?Rabbit Anti-OGG1 antibody

產(chǎn)品編號(hào)：ZIKER-3687R
英文名稱：OGG1

規(guī)格：50ul  100ul  200ul
中文名稱：8-羥基鳥(niǎo)嘌呤DNA糖基化酶
別    名：8 hydroxyguanine DNA glycosylase; 8 oxoguanine DNA glycosylase 1; 8-oxoguanine DNA glycosylase; AP lyase; DNA apurinic or apyrimidinic site lyase; DNA lyase; DNA-(apurinic or apyrimidinic site) lyase; HMMH; HOGG 1; HOGG1; MMH; MUTM; N-glycosylase; Ogg 1; OGH 1; OGH1; OGG1_HUMAN.  
研究領(lǐng)域：細(xì)胞生物  免疫學(xué)  染色質(zhì)和核信號(hào)  線粒體  
抗體來(lái)源：Rabbit
克隆類型：Polyclonal
交叉反應(yīng): Human, Mouse, Rat, Dog, Pig, Cow, 
產(chǎn)品應(yīng)用:WB=1:500-2000 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1ug/Test IF=1:100-500 （石蠟切片需做抗原修復(fù)） .

not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量:38-47kDa
細(xì)胞定位:細(xì)胞核 細(xì)胞漿 線粒體
性    狀:Lyophilized or Liquid
濃    度:1mg/ml
免 疫 原:KLH conjugated synthetic peptide derived from human OGG1/8 hydroxyguanine DNA glycosylase:151-250/424 
亞    型:IgG
純化方法:affinity purified by Protein A
儲(chǔ) 存 液:0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件:Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMedPubMed
產(chǎn)品介紹 :This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share the N-terminal region in common, which contains a mitochondrial targeting signal that is essential for mitochondrial localization. Many alternative splice variants for this gene have been described, but the full-length nature for every variant has not been determined. [provided by RefSeq, Aug 2008].

Function:
DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion.

Subcellular Location:
Mitochondrion; Nucleus and Nucleus > nucleoplasm. Nucleus speckle. Nucleus matrix. Together with APEX1 is recruited to nuclear speckles in UVA-irradiated cells.

Tissue Specificity:
Ubiquitous.

DISEASE:
Defects in OGG1 may be a cause of renal cell carcinoma (RCC) [MIM:144700]. It is a heterogeneous group of sporadic or hereditary carcinoma derived from cells of the proximal renal tubular epithelium. It is subclassified into clear cell renal carcinoma (non-papillary carcinoma), papillary renal cell carcinoma, chromophobe renal cell carcinoma, collecting duct carcinoma with medullary carcinoma of the kidney, and unclassified renal cell carcinoma.

Similarity:
Belongs to the type-1 OGG1 family.

SWISS:
O15527

Gene ID:
4968

Database links:
Entrez Gene: 4968 Human

Entrez Gene: 18294 Mouse

Omim: 601982 Human

SwissProt: O15527 Human

SwissProt: O08760 Mouse

Unigene: 380271 Human

Unigene: 43612 Mouse


Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications
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